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br CL siSOX inhibits expression markers of tumor growth br
2020-08-30
CL-siSOX2 inhibits expression markers of tumor growth Discussion The SOX2 embryonic stem cell marker has gained attention for its wide-ranging transcriptional effects on enabling tumor growth and resistance in different types of cancer; for example, SOX2 promoted tumor growth and acquired re
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br Introduction br Mitochondria are the powerhouse of the
2020-08-30
1. Introduction Mitochondria are the powerhouse of the cell and serve as an at-tractive target for cancer treatment. In cellular processes, these orga-nelles provide 3X FLAG Peptide through oxidative phos-phorylation, constitute the main source of reactive oxygen species (ROS), and participate
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br should be referred to
2020-08-28
should be referred to a cardiologist [120]. After 10 years, stress testing should be performed even in asymptomatic cancer survivors (echocar-diography, MRI, scintigraphy) [15]. 9. Conclusions and perspective Due to better tolerability and precision of modern cancer therapies, more patients
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i u du br According
2020-08-28
i ( u )du According to the multiplicative risk model, that is the excess relative risk model, animals exposed to a daily dose D have the cumulative hazard function: t and the cumulative risk among animals exposed to a daily dose D, Pi(D), will thus be: e The observed number of glycido
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br Risk stratification will be used to guide women to
2020-08-18
Risk-stratification will be used to guide women to an adequate screening modality The modality developments described above could increase the proportion of cancers that are detected at an early, curable, stage. However, they also increase the time and cost of screening. Therefore, it is possib
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br LC MS analyses in
2020-08-18
LC-MS analyses in SWATH-MS mode SWATH-MS datasets of the individual patients were acquired on a TripleTOF 5600+ mass spectrometer (SCIEX, Canada); the same chromatographic system, settings, and gradient conditions as described above for spectral library generation were used. Using an isolation
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It would be valuable to know
2020-08-18
It would be valuable to know whether it is cost-effective to offer BRCA Calpain Inhibitor I ALLN testing to all first-degree relatives of women with HGSC, alive or deceased, whose BRCA mutation status is unknown. This question cannot be answered in the context of a clinical trial. The objective of t
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br and micelles Conjugation of curcumin to a
2020-08-18
[19] and micelles [20–22]. Conjugation of curcumin to a hydrophilic polymer is another way of tackling this problem. Polymer conjugates have an advantageous drug-to-excipient ratio compared to other, mentioned above systems, what reduces their potential to induce un-desired side effects. Additional
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br Immunohistochemistry and western blot analyses were
2020-08-18
Immunohistochemistry and western blot analyses were performed on transformed versus wild-type organoids on day 10 after infection (Fig. 2F). Expression of KrasG12D and deletion of P53 in transformed organoids were associated with BIRC5 upregulation (Fig. 2H, upper panel), whereas absence of
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br Targeting Specific Cell Populations br Cellular
2020-08-18
2.1 Targeting Specific Cell Populations Cellular targeting has been extensively studied as a solution to improve intratumoral and cell type-specific NP delivery. This can be accomplished by the incorporation of specific molecular tags on the particle surface that can interact with extracellular
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br BCG induced NETs are potent activators of
2020-08-18
3.4. BCG-induced NETs are potent activators of PBMCs, in which NETs' protein components play a key role To determine whether cellular immunity was induced, we exposed PBMCs to NETs prepared from the same donor neutrophils. NETs in-duced IFN-γ, IL-2, and TNF-α in a negative dose-dependent manner
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br A greater adaptive flexibility may contribute to
2020-08-18
A greater adaptive flexibility may contribute to the protective effect of attachment security on depression and anxiety that has been de-monstrated empirically in advanced cancer [7]. In that regard, the meta-analysis of Nissen et al. [8] suggests an inverse relationship be-tween attachment securit
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br The region containing TP polymorphism was PCR amplified
2020-08-18
The region containing TP53 polymorphism was PCR-amplified by ARMS-PCR method using forward and reverse primers 5′- TCCCCCTT GCCGTCCCAA-3′ and 5′-CTGGTGCAGGGGCCACGC-3 respectively for Arginine, forward and reverse primers 5′-GCCAGAGGCTGCTCCCCC-3′ and 5′-CGTGCAAGTCACAGACTT-3′ respectively for Prolin
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br Introduction br Breast cancer is
2020-08-14
1. Introduction Breast cancer is the most common cancer among women worldwide [1] and is triggered by several risk factors. Its occurrence and devel-opment are multi-factorial and hormonal-dependent processes. The availability of sophisticated high-throughput technology, together with well-d
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br Fig In vivo antitumor effects of BMS in SKOV
2020-08-12
Fig. 4. In vivo antitumor effects of BMS-777607 in SKOV3 Trametinib constitutively expressing phosphorylated c-MET 50 mg/kg of BMS-777607 daily was orally administered to SKOV3 cell xenograft nude mice (water was administered to the control mice). The tumor sizes were monitored using an IVIS syst