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br Study concept and design All authors br Acquisition of
2019-09-23
Study concept and design: All authors. Acquisition of data: Hugosson, Roobol, Tammela, Zappa, Nelen, Denis, Kwiatkowski, Lujan, Carlsson, Recker, Paez, Puliti, Villers, Rebillard, Bangma, Schröder, Auvinen. Analysis and interpretation of data: Hugosson, Roobol, Månsson, Auvinen. Drafti
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br Immunoblotting br Aliquots of control and knockout or
2019-09-23
2.6. Immunoblotting Aliquots of control and knockout or knockdown cell lines prepared as IHC controls were harvested, washed in calcium- and magnesium-free Dulbecco's phosphate buffered saline (PBS), sonicated in buffered 6 M guanidine hydrochloride under reducing conditions, and prepared for e
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br Acknowledgments This research was conducted
2019-09-16
Acknowledgments—This research was conducted in the framework of the IMPULS2 program in collaboration with Philips and also received funding from the Dutch Cancer Society (#UVA2013-5941), and the National Natural Science Foundation of China (#81420108018 and #81527803), the Zhejiang Science and Tec
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CY7-SE br Conflict of interest br
2019-09-16
Conflict of interest The authors declare no potential conflict of interest with respect to the authorship and/or publication of this article. Appendix A. Supporting information References Song, L., Wang, Z., Wang, Y., Guo, D., Yang, J., Chen, L., Tan, N., 2017. Natural cyclo-peptide RA
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br The human breast carcinoma cell
2019-09-16
The human breast carcinoma cell lines (MCF-7, MDA-MB-453, BT-474, MDA-MB-468 and MDA-MB-231) were obtained from China Infra-structure of Cell Line Resources, which cultured in DMEM medium sup-plemented with 10% fetal bovine serum (Gibco), 100 U/mL penicillin, and 100 mg/mL streptomycin (Beyotime,
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In the present surgical cohort we aimed to evaluate
2019-08-26
In the present surgical cohort, we aimed to evaluate c-MET as a prognostic and/or predictive biomarker and identify a c-MET H-score cut-off value with a prognostic or predictive clinical utility. The univariate analysis done in the whole study population failed to show any significant benefit for an
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br Discussion Our findings have important clinical implicati
2019-08-26
Discussion Our findings have important clinical implications for both clinicians and patients. In routine clinical practice, treatment response can only be assessed at around 3 months, since radiological imaging earlier is thought to be uninformative; CT scans in clinical trials are typically con
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br Conclusions br Conflicts of interest br Introduction
2019-08-26
Conclusions Conflicts of interest Introduction Small-cell lung cancer (SCLC) represents an aggressive disease, which is intrinsically predisposed to a fast and early metastatization [1]. This peculiar natural history drives the dismal outcome of SCLC patients, whose prognosis has remained u
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Misclassification of the cause of death in national death re
2019-08-26
Misclassification of the cause of death in national death registries and death certificates can have implications for cause-specific mortality analysis as demonstrated by Hoffmann et al. [7].This study validated death certificates in New Mexico, USA and demonstrated that attribution bias overestimat
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br Methods br Results As shown
2019-08-26
Methods Results As shown in Table 1, the cases were older, with a higher proportion of women, with more education than the control group. The predominant cancer subsite was oral cavity cancer. Among never tobacco smokers, involuntary smoking was associated with a 1.47-fold increase in risk of
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M3814 (nedisertib) For localized prostate cancer many risk c
2019-08-16
For localized prostate cancer, many risk classifications have been developed in order to predict the course of the disease and to improve treatment selection [[18], [19], [20]] in which TNM classification, WHO grade group/Gleason score and PSA value have the strongest correlation with the oncologic
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The model accuracy is as good as the data input
2019-08-11
The model accuracy is as good as the data input, and the assumptions made for the different scenarios. The data validity for CRC incidence provided by NORDCAN is high [23]; valid and representative Seladelpar data on meat intake exists for a broad age span in Denmark; and the DANSDA survey provides
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The results of the bivariate analysis between the dependent
2019-08-11
The results of the bivariate analysis between the dependent variables (anxiety and depression) and the independent variables are shown in Table 2. We observed significant differences in anxiety and depression between social classes, with women in the lower social class having more anxiety and depres
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We reviewed the literature for
2019-08-11
We reviewed the literature for other studies of preferred beverage temperature [[16], [17], [18],23,[31], [32], [33], [34], [35], [36], [37], [38], [39], [40]], (Table 4), and found that the mean preferred tea temperature in our study was 1.5 °C higher than any other studied population. It should be
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In contrast to the preimplantation blastocyst phenotype we h
2019-08-11
In contrast to the preimplantation blastocyst phenotype, we have found that embryo culture in depleted insulin and BCAA replicates well the postnatal phenotype programmed by Emb-LPD. How might these long-term outcomes be so induced by periconceptional metabolite levels? Increased fetus and birth wei